{"id":3075,"date":"2022-10-24T15:41:50","date_gmt":"2022-10-24T15:41:50","guid":{"rendered":"https:\/\/seaco.vn\/en\/?p=3075"},"modified":"2022-10-24T15:41:50","modified_gmt":"2022-10-24T15:41:50","slug":"nha-khoa-hoc-viet-tim-ra-chat-uc-che-te-bao-ung-thu-mau-tu-gao","status":"publish","type":"post","link":"https:\/\/seaco.vn\/en\/nha-khoa-hoc-viet-tim-ra-chat-uc-che-te-bao-ung-thu-mau-tu-gao\/","title":{"rendered":"Nh\u00e0 khoa h\u1ecdc Vi\u1ec7t t\u00ecm ra ch\u1ea5t \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u t\u1eeb g\u1ea1o"},"content":{"rendered":"<p class=\"description\">GS.TS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n v\u00e0 c\u1ed9ng s\u1ef1 ch\u1ee9ng minh ch\u1ea5t Momilactones A v\u00e0 B trong g\u1ea1o c\u00f3 t\u00e1c d\u1ee5ng th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ef1 ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a c\u00e1c protein.<\/p>\n<article class=\"fck_detail \">\n<p class=\"Normal\">Nghi\u00ean c\u1ee9u do GS.TS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n, Tr\u01b0\u1edfng ph\u00f2ng th\u00ed nghi\u1ec7m Sinh l\u00fd th\u1ef1c v\u1eadt v\u00e0 H\u00f3a sinh, \u0110\u1ea1i h\u1ecdc Hiroshima (Nh\u1eadt B\u1ea3n) v\u1edbi \u0111\u1ed3ng nghi\u1ec7p, g\u1ed3m Tr\u1ee3 l\u00fd Gi\u00e1o s\u01b0 TS Nguy\u1ec5n V\u0103n Qu\u00e2n, TS L\u00e3 Ho\u00e0ng Anh, c\u00f9ng GS.TS Takami Akiyoshi v\u00e0 Th\u1ea1c s\u0129 V\u0169 Quang L\u00e2m t\u1ea1i \u0110\u1ea1i h\u1ecdc Y khoa Aichi th\u1ef1c hi\u1ec7n, \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Cancers v\u1ec1 ti\u1ec1m n\u0103ng ch\u1ed1ng ung th\u01b0 m\u00e1u c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t momilactone A v\u00e0 B (MA v\u00e0 MB) chi\u1ebft xu\u1ea5t t\u1eeb l\u00faa g\u1ea1o, h\u1ed3i \u0111\u1ea7u th\u00e1ng 10.<\/p>\n<p><img loading=\"lazy\" class=\"wp-image-3230 aligncenter\" src=\"https:\/\/seaco.vn\/wp-content\/uploads\/2022\/10\/9732-1666531975.jpg\" alt=\"\" width=\"649\" height=\"469\" \/><\/p>\n<p style=\"text-align: center;\">Hai h\u1ee3p ch\u1ea5t Momilactone A v\u00e0 B \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1ea1i ph\u00f2ng th\u00ed nghi\u1ec7m Sinh l\u00fd Th\u1ef1c v\u1eadt v\u00e0 Sinh h\u00f3a, \u0110\u1ea1i h\u1ecdc Hiroshima. \u1ea2nh:\u00a0<em>NVCC<\/em><\/p>\n<p class=\"Normal\">Trong nghi\u00ean c\u1ee9u n\u00e0y, l\u1ea7n \u0111\u1ea7u ti\u00ean c\u00e1c nh\u00e0 khoa h\u1ecdc ch\u1ec9 ra ti\u1ec1m n\u0103ng ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u bao g\u1ed3m l\u01a1 x\u00ea mi c\u1ea5p ti\u1ec1n tu\u1ef7 b\u00e0o v\u00e0 \u0111a u tu\u1ef7 x\u01b0\u01a1ng c\u1ee7a Momilactones A, B (MA, MB) c\u00f9ng h\u1ed7n h\u1ee3p c\u1ee7a ch\u00fang (MAB) v\u1edbi t\u1ef7 l\u1ec7 1:1. C\u1ee5 th\u1ec3, MB v\u00e0 MAB cho th\u1ea5y kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi thu\u1ed1c ch\u1eefa ung th\u01b0 ph\u1ed5 bi\u1ebfn l\u00e0 doxorubicin v\u00e0 arsenic trioxide (ATO), t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi all-trans retinoic acid (ATRA).<\/p>\n<p class=\"Normal\">B\u1eb1ng c\u00e1c th\u00ed nghi\u1ec7m chuy\u00ean s\u00e2u, GS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 l\u00e0m r\u00f5 c\u01a1 ch\u1ebf ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 c\u1ee7a momilactone. C\u1ee5 th\u1ec3, c\u00e1c h\u1ee3p ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ef1 ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a c\u00e1c protein li\u00ean quan (p-38, BCL-2, v\u00e0 caspase-3). Ngo\u00e0i ra, momilactone c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n chu k\u1ef3 t\u1ebf b\u00e0o t\u1ea1i pha G2 b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t protein p-38 v\u00e0 \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ph\u1ee9c h\u1ee3p CDK1 v\u00e0 cyclin B1. B\u1eb1ng c\u00e1ch \u0111\u00f3, momilactone l\u00e0m t\u1ebf b\u00e0o ung th\u01b0 kh\u00f4ng th\u1ec3 ph\u00e2n chia \u0111\u01b0\u1ee3c. \u0110\u1eb7c bi\u1ec7t, momilactone cho th\u1ea5y \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn t\u1ebf b\u00e0o kho\u1ebb m\u1ea1nh.<\/p>\n<p class=\"Normal\">Vi\u1ec7c ph\u00e1t hi\u1ec7n \u0111\u1eb7c t\u00ednh g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o ch\u1ed1ng l\u1ea1i t\u1ebf b\u00e0o ung th\u01b0 c\u1ee7a momilactone \u0111\u01b0\u1ee3c k\u1ef3 v\u1ecdng l\u00e0 ti\u1ec1n \u0111\u1ec1 cho c\u00e1c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 hi\u1ec7u qu\u1ea3 d\u1ef1a tr\u00ean momilactone trong t\u01b0\u01a1ng lai.<\/p>\n<p class=\"Normal\">Nh\u00f3m cho bi\u1ebft s\u1ebd ti\u1ebfp t\u1ee5c c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn sinh h\u1ecdc v\u00e0 kh\u1ea3 d\u1ee5ng sinh h\u1ecdc th\u00f4ng qua c\u00e1c th\u1eed nghi\u1ec7m tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ti\u1ebfp theo.<\/p>\n<p class=\"Normal\">Tr\u01b0\u1edbc \u0111\u00e2y, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u t\u1eebng ch\u1ec9 ra ti\u1ec1m n\u0103ng ch\u1ed1ng ung th\u01b0 c\u1ee7a momilactones, tuy nhi\u00ean, c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o ch\u01b0a \u0111\u01b0\u1ee3c xem x\u00e9t k\u1ef9 l\u01b0\u1ee1ng. S\u1edf d\u0129 c\u00e1c nghi\u00ean c\u1ee9u chuy\u00ean s\u00e2u v\u1ec1 h\u1ee3p ch\u1ea5t n\u00e0y v\u1eafng b\u00f3ng tr\u00ean th\u1ebf gi\u1edbi do h\u1ee3p ch\u1ea5t &#8220;\u0111\u1eaft h\u01a1n v\u00e0ng 30 ngh\u00ecn l\u1ea7n&#8221; n\u00e0y kh\u00f4ng c\u00f3 s\u1eb5n tr\u00ean th\u1ecb tr\u01b0\u1eddng, c\u0169ng nh\u01b0 kh\u00f3 kh\u0103n trong vi\u1ec7c ph\u00e2n l\u1eadp v\u00e0 tinh ch\u1ebf.<\/p>\n<p class=\"Normal\">Ph\u00f2ng th\u00ed nghi\u1ec7m Sinh l\u00fd th\u1ef1c v\u1eadt v\u00e0 H\u00f3a sinh, \u0110\u1ea1i h\u1ecdc Hiroshima do GS Xu\u00e2n \u0111\u1ee9ng \u0111\u1ea7u l\u00e0 m\u1ed9t trong s\u1ed1 \u00edt c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m tr\u00ean th\u1ebf gi\u1edbi c\u00f3 th\u1ec3 tinh ch\u1ebf momilactones t\u1eeb c\u00e1c ngu\u1ed3n t\u1ef1 nhi\u00ean.<\/p>\n<p><img loading=\"lazy\" class=\"wp-image-3231 aligncenter\" src=\"https:\/\/seaco.vn\/wp-content\/uploads\/2022\/10\/7182-1666531975.jpg\" alt=\"\" width=\"616\" height=\"422\" \/><\/p>\n<p style=\"text-align: center;\"><em>GS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n (b\u00eca ph\u1ea3i) v\u00e0 nghi\u00ean c\u1ee9u vi\u00ean t\u1ea1i Ph\u00f2ng th\u00ed nghi\u1ec7m sinh l\u00fd, th\u1ef1c v\u1eadt v\u00e0 h\u00f3a sinh. \u1ea2nh:\u0110\u1ea1i h\u1ecdc Hiroshima.<\/em><\/p>\n<p>Trong c\u00f4ng b\u1ed1 h\u1ed3i th\u00e1ng 1\/2019, nh\u00f3m t\u00ecm th\u1ea5y v\u00e0 ph\u00e2n l\u1eadp th\u00e0nh c\u00f4ng hai h\u1ee3p ch\u1ea5t n\u00e0y t\u1eeb tr\u1ea5u v\u00e0 g\u1ea1o tr\u1eafng. T\u1eeb 20 kg v\u1ecf tr\u1ea5u, sau g\u1ea7n 3 th\u00e1ng, kho\u1ea3ng 300 mg MA v\u00e0 200 mg MB (chi\u1ebfm kho\u1ea3ng 1\/100 -150 ngh\u00ecn tr\u1ecdng l\u01b0\u1ee3ng v\u1ecf tr\u1ea5u) \u0111\u01b0\u1ee3c t\u00e1ch chi\u1ebft. H\u1ee3p ch\u1ea5t n\u00e0y t\u1eebng \u0111\u01b0\u1ee3c trang \u0111i\u1ec7n t\u1eed Carbosynth.com, m\u1ed9t c\u00f4ng ty chuy\u00ean v\u1ec1 c\u00e1c s\u1ea3n ph\u1ea9m h\u00f3a sinh n\u1ed5i ti\u1ebfng c\u1ee7a Anh b\u00e1n v\u1edbi gi\u00e1 1.25 tri\u1ec7u USD cho 1g (\u0111\u1eaft g\u1ea5p 30 ngh\u00ecn l\u1ea7n gi\u00e1 tr\u1ecb 1g v\u00e0ng). Trong c\u00e1c nghi\u00ean c\u1ee9u sau \u0111\u00f3, hai h\u1ee3p ch\u1ea5t qu\u00fd n\u00e0y c\u0169ng cho th\u1ea5y c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf ti\u1ec3u \u0111\u01b0\u1eddng, b\u00e9o ph\u00ec.<\/p>\n<p><strong>Ngu\u1ed3n: <a href=\"https:\/\/vnexpress.net\/nha-khoa-hoc-viet-tim-ra-chat-uc-che-te-bao-ung-thu-mau-tu-gao-4525842.html\">VNExpress<\/a><\/strong><\/p>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>GS.TS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n v\u00e0 c\u1ed9ng s\u1ef1 ch\u1ee9ng minh ch\u1ea5t Momilactones A v\u00e0 B trong g\u1ea1o c\u00f3 t\u00e1c d\u1ee5ng th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ef1 ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a c\u00e1c protein. Nghi\u00ean c\u1ee9u do GS.TS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n, Tr\u01b0\u1edfng ph\u00f2ng th\u00ed nghi\u1ec7m Sinh l\u00fd th\u1ef1c v\u1eadt v\u00e0 H\u00f3a sinh, [&#8230;]\n","protected":false},"author":1,"featured_media":3076,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[315],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nh\u00e0 khoa h\u1ecdc Vi\u1ec7t t\u00ecm ra ch\u1ea5t \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u t\u1eeb g\u1ea1o - Seaconsult Joint Stock Company<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seaco.vn\/en\/nha-khoa-hoc-viet-tim-ra-chat-uc-che-te-bao-ung-thu-mau-tu-gao\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nh\u00e0 khoa h\u1ecdc Vi\u1ec7t t\u00ecm ra ch\u1ea5t \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u t\u1eeb g\u1ea1o - Seaconsult Joint Stock Company\" \/>\n<meta property=\"og:description\" content=\"GS.TS Tr\u1ea7n \u0110\u0103ng Xu\u00e2n v\u00e0 c\u1ed9ng s\u1ef1 ch\u1ee9ng minh ch\u1ea5t Momilactones A v\u00e0 B trong g\u1ea1o c\u00f3 t\u00e1c d\u1ee5ng th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ef1 ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 m\u00e1u b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a c\u00e1c protein. 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